Discovery and saturation analysis of cancer genes across 21 tumour types

by Lawrence, Michael S., Stojanov, Petar, Mermel, Craig H., Robinson, James T., Garraway, Levi A., Golub, Todd R., Meyerson, Matthew L., Gabriel, Stacey B., Getz, Gad, Lander, Eric Steven
Published 2015

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

by Sankaran, Vijay G., Menne, Tobias F., Scepanovic, Danilo, Vergilio, Jo-Anne, Ji, Peng, Kim, Jinkuk, Thiru, Prathapan, Orkin, Stuart H., Lander, Eric Steven, Lodish, Harvey F
Published 2011

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel

by Mitt, Mario, Kals, Mart, Pärn, Kalle, Ripatti, Samuli, Morris, Andrew P, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Palta, Priit, Gabriel, Stacey, Lander, Eric Steven, Palotie, Aarno
Published 2018

RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites

by Sirokman, Klara, McDonel, Patrick, Shishkin, Alexander A., Surka, Christine, Russell, Pamela, Chow, Amy Y., Guttman, Mitchell, Lander, Eric Steven, Engreitz, Jesse Michael, Grossman, Sharon Rachel
Published 2017

Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network

by Aiden, Aviva Presser, Rivera, Miguel N., Rheinbay, Esther, Ku, Manching, Coffman, Erik J., Truong, Thanh T., Vargas, Sara O., Haber, Daniel A., Bernstein, Bradley E., Lander, Eric Steven
Published 2012

Mining data from 1000 genomes to identify the causal variant in regions under positive selection

by Grossman, Sharon Rachel, Karlsson, Elinor K., Tabrizi, Shervin, Andersen, Kristian G., Rinn, John L., Lander, Eric S., Schaffner, Steve, Sabeti, Pardis C., 1000 Genomes Project Consortium, Shlyakhter, Ilya, 1975-
Published 2012

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

by Khera, Amit V., Chaffin, Mark, Aragam, Krishna G., Haas, Mary E., Roselli, Carolina, Choi, Seung Hoan, Natarajan, Pradeep, Lander, Eric Steven, Lubitz, Steven A., Ellinor, Patrick T., Kathiresan, Sekar
Published 2020

Systematic dissection of genomic features determining transcription factor binding and enhancer function

by Zhang, Xiaolan, Wang, Li, Melnikov, Alexandre, Rogov, Peter, Tewhey, Ryan, Isakova, Alina, Deplancke, Bart, Bernstein, Bradley E., Mikkelsen, Tarjei S., Grossman, Sharon Rachel, Engreitz, Jesse Michael, Lander, Eric Steven
Published 2017

De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds

by Dudchenko, Olga, Batra, Sanjit S., Omer, Arina D., Hoeger, Marie, Durand, Neva C., Shamim, Muhammad S., Machol, Ido, Aiden, Aviva Presser, Aiden, Erez Lieberman, Nyquist, Sarah Kate, Lander, Eric Steven
Published 2018

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

by Engreitz, Jesse Michael, Pandya-Jones, Amy, McDonel, Patrick, Shishkin, Alexander, Sirokman, Klara, Surka, Christine, Kadri, Sabah, Xing, Jeffrey, Goren, Alon, Plath, Kathrin, Guttman, Mitchell, Lander, Eric Steven
Published 2014

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

by Proia, Theresa A., Keller, Patricia J., Klebba, Ina, Jones, Ainsley D., Sedic, Maja, Gilmore, Hannah, Tung, Nadine, Naber, Stephen P., Schnitt, Stuart, Gupta, Piyush, Kuperwasser, Charlotte, Lander, Eric Steven
Published 2014

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

by Park, Daniel S., Liu, Brandon, Winnicki, Sarah, Reilly, Steven K., Andersen, Kristian G., Tewhey, Ryan, Kotliar, Dylan A., Andersen, Kristian, Mikkelsen, Tarjei, Lander, Eric Steven, Schaffner, Stephen F, Sabeti, Pardis
Published 2018

Ab initio reconstruction of transcriptomes of pluripotent and lineage committed cells reveals gene structures of thousands of lincRNAs

by Guttman, Mitchell, Garber, Manuel, Levin, Joshua Z., Donaghey, Julie, Robinson, James, Adiconis, Xian, Fan, Lin, Koziol, Magdalena J., Gnirke, Andreas, Nusbaum, Chad, Rinn, John L., Regev, Aviv, Lander, Eric Steven
Published 2012

Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution

by Kasar, S., Kim, J., Improgo, R., Tiao, G., Polak, P., Haradhvala, N., Lawrence, M. S., Kiezun, A., Fernandes, S. M., Bahl, S., Sougnez, C., Gabriel, S., Kim, H. T., Getz, G., Brown, J. R., Lander, Eric Steven
Published 2017

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

by Yassour, Moran, Vatanen, Tommi, Siljander, Heli, Hämäläinen, Anu-Maaria, Härkönen, Taina, Ryhänen, Samppa J., Franzosa, Eric A., Vlamakis, Hera, Huttenhower, Curtis, Gevers, Dirk, Knip, Mikael, Lander, Eric Steven, Xavier, Ramnik Joseph
Published 2018

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

by Schwartz, Schraga, Bernstein, Douglas A., Mumbach, Maxwell R., Jovanovic, Marko, Herbst, Rebecca H., León-Ricardo, Brian X., Guttman, Mitchell, Satija, Rahul, Fink, Gerald, Engreitz, Jesse Michael, Lander, Eric Steven, Regev, Aviv
Published 2017

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

by Presser, Aviva, Guttman, Mitchell, Raj, Arjun, van Oudenaarden, Alexander, Rinn, John L., Lander, Eric S., Regev, Aviv, Bernstein, Bradley E., Thomas, Kelly, Morales, Dianali Rivea, Garber, Manuel, Khalil, Ahmad M., Huarte, Maite
Published 2010

Rapid dissection and model-based optimization of inducible enhancers in human cells using a massively parallel reporter assay

by Melnikov, Alexandre, Murugan, Anand, Zhang, Xiaolan, Tesileanu, Tiberiu, Wang, Li, Rogov, Peter, Feizi-Khankandi, Soheil, Gnirke, Andreas, Callan Jr, Curtis G., Kinney, Justin B., Kellis, Manolis, Lander, Eric S., Mikkelsen, Tarjei Sigurd, 1978-
Published 2012

Delivery Mode Affects Stability of Early Infant Gut Microbiota

by Mitchell, Caroline M, Mazzoni, Chiara, Hogstrom, Larson, Bryant, Allison, Bergerat, Agnes, Cher, Avital, Pochan, Shawna, Herman, Penelope, Carrigan, Maureen, Sharp, Karen, Huttenhower, Curtis, Lander, Eric S, Vlamakis, Hera, Xavier, Ramnik J, Yassour, Moran
Published 2021

High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis

by Schwartz, Schraga, Mumbach, Maxwell R., Jovanovic, Marko, Mertins, Philipp, Shishkin, Alexander, Tabach, Yuval, Mikkelsen, Tarjei S., Satija, Rahul, Ruvkun, Gary, Carr, Steven A., Regev, Aviv, Agarwala, Sudeep, Lander, Eric Steven, Fink, Gerald R.
Published 2017