Optogenetic activation of intracellular adenosine A[subscript 2A] receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer’s disease through the antagonism of adenosine A2A receptors (A2ARs). To test if A2AR activation in the hippocampus is actually sufficient to impair memory function and to begi...

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Main Authors: Li, P., Rial, D., Canas, P. M., Yoo, J.-H., Li, W., Zhou, X., Wang, Y., van Westen, G. J. P., Payen, M.-P., Augusto, E., Gonçalves, N., Tomé, A. R., Li, Z., Wu, Z., Hou, X., Zhou, Y., PIJzerman, Ad, Boyden, Edward Stuart, Cunha, R. A., Qu, J., Chen, J.-F.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2016
Online Access:http://hdl.handle.net/1721.1/103590
https://orcid.org/0000-0002-0419-3351
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