The Transcription Factors T-bet and GATA-3 Control Alternative Pathways of T-cell Differentiation Through a Shared Set of Target Genes
Upon detection of antigen, CD4+ T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the transcription factors T-bet and GATA-3, respectively. Only a handful of target genes a...
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Main Authors: | , , , , , , , |
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Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2010
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Online Access: | http://hdl.handle.net/1721.1/58303 https://orcid.org/0000-0001-8855-8647 |
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