The Transcription Factors T-bet and GATA-3 Control Alternative Pathways of T-cell Differentiation Through a Shared Set of Target Genes

Upon detection of antigen, CD4+ T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the transcription factors T-bet and GATA-3, respectively. Only a handful of target genes a...

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Bibliographic Details
Main Authors: Young, Richard A., Jenner, Richard G., Townsend, Michael J., Jackson, Ian, Sun, Kaiming, Bouwman, Russell D., Glimcher, Laurie H., Lord, Graham M.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2010
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Online Access:http://hdl.handle.net/1721.1/58303
https://orcid.org/0000-0001-8855-8647
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