Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy

Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy

Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of hum...

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Main Authors: Raja, Anju M., Xu, Shuoyu, Sun, Wanxin, Zhou, Jianbiao, Tai, Dean C. S., Chen, Chien Shing, Rajapakse, Jagath, So, Peter T. C., Yu, Hanry
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Society of Photo-optical Instrumentation Engineers 2011
Online Access:http://hdl.handle.net/1721.1/64972
https://orcid.org/0000-0002-0339-3685
https://orcid.org/0000-0003-4698-6488
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http://hdl.handle.net/1721.1/64972
https://orcid.org/0000-0002-0339-3685
https://orcid.org/0000-0003-4698-6488

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