Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration to induce an inflammatory background have successfully reproduced idiosyncratic...

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Bibliographic Details
Main Authors: Xu, Jinghai J., Hendriks, Bart S., Cosgrove, Benjamin D., King, Bracken Matheny, Hasan, Maya A., Alexopoulos, Leonidas G., Farazi, Paraskevi A., Sorger, Peter K., Tidor, Bruce, Griffith, Linda G., Lauffenburger, Douglas A.
Other Authors: Massachusetts Institute of Technology. Biotechnology Process Engineering Center
Format: Article
Published: Elsevier Ltd. 2011
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