Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH-Mutant Gliomas

Purpose: Isocitrate dehydrogenase (IDH) gene mutations occur in low-grade and high-grade gliomas. We sought to identify the genetic basis of malignant phenotype heterogeneity in IDH-mutant gliomas. Methods: We prospectively implanted tumor specimens from 20 consecutive IDH1-mutant glioma resections...

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Main Authors: Wakimoto, H., Tanaka, S., Curry, W. T., Loebel, F., Zhao, D., Tateishi, K., Chen, J., Klofas, L. K., Lelic, N., Kim, J. C., Dias-Santagata, D., Ellisen, L. W., Borger, D. R., Fendt, Sarah-Maria, Batchelor, Tracy T., Iafrate, A. John, Cahill, D. P., Chi, A. S., Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for Cancer Research 2015
Online Access:http://hdl.handle.net/1721.1/96830
https://orcid.org/0000-0002-6702-4192
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