Dystrophic spinal deformities in a neurofibromatosis type 1 murine model

Dystrophic spinal deformities in a neurofibromatosis type 1 murine model

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Despite the high prevalence and significant morbidity of spinal anomalies in neurofibromatosis type 1 (NF1), the pathogenesis of these defects remains largely unknown. Here, we present two murine models: Nf1flox/-;PeriCre and Nf1flox/-;Col.2.3Cre mice, which recapitulate spinal deformities seen in t...

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Bibliographic Details
Main Authors: Rhodes, Steven D., Zhang, Wei, Yang, Dalong, Yang, Hao, Chen, Shi, Wu, Xiahoua, Yang, Xianlin, Mohammad, Khalid S., Guise, Theresa A., Bergner, Amanda L., Stevenson, David A., Yang, Feng-Chun
Other Authors: Department of Anatomy and Cell Biology, IU School of Medicine
Format: Article
Language:en_US
Published: PLoS 2016
Subjects:
Animals
Bone Remodeling
Cervical Vertebrae
Disease Models, Animal
Females
Mice
Neurofibromatosis 1
Spine
Online Access:http://hdl.handle.net/1805/10022
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http://hdl.handle.net/1805/10022

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