Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene

Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene

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Bone remodeling is controlled by the actions of bone-degrading osteoclasts and bone-forming osteoblasts (OBs). Aging and loss of estrogen after menopause affects bone mass and quality. Estrogen therapy, including selective estrogen receptor modulators (SERMs), can prevent bone loss and increase bone...

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Bibliographic Details
Main Authors: Posritong, Sumana, Hong, Jung Min, Eleniste, Pierre P., McIntyre, Patrick W., Wu, Jennifer L., Himes, Evan R., Patel, Vruti, Kacena, Melissa A., Bruzzaniti, Angela
Other Authors: Biomedical Sciences and Comprehensive Care, School of Dentistry
Format: Article
Language:en_US
Published: Elsevier 2020
Subjects:
Bone formation
Estrogen receptor
Mineralization
Osteoblast
Pyk2
SERMs
Online Access:http://hdl.handle.net/1805/21740
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http://hdl.handle.net/1805/21740

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