Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development

Adaptation to low oxygen tension (hypoxia) is a critical event during development. The transcription factors Hypoxia Inducible Factor-1α (HIF-1α) and HIF-2α are essential mediators of the homeostatic responses that allow hypoxic cells to survive and differentiate. Von Hippel Lindau protein (VHL) is...

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Main Authors: Mangiavini, Laura, Merceron, Christophe, Araldi, Elisa, Khatri, Richa, Gerard-O'Riley, Rita, Wilson, Tremika LeShan, Rankin, Erinn B., Giaccia, Amato J., Schipani, Ernestina
Other Authors: Department of Medicine, Division of General Internal Medicine, IU School of Medicine
Format: Article
Language:en_US
Published: Elsevier 2016
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Online Access:http://hdl.handle.net/1805/8383
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