Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development
Adaptation to low oxygen tension (hypoxia) is a critical event during development. The transcription factors Hypoxia Inducible Factor-1α (HIF-1α) and HIF-2α are essential mediators of the homeostatic responses that allow hypoxic cells to survive and differentiate. Von Hippel Lindau protein (VHL) is...
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Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | en_US |
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Elsevier
2016
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Online Access: | http://hdl.handle.net/1805/8383 |
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