Structure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy

The human chaperonin TRiC consists of eight non-identical subunits, and its protein-folding activity is critical for cellular health. Misfolded proteins are associated with many human diseases, such as amyloid diseases, cancer, and neuropathies, making TRiC a potential therapeutic target. A detailed...

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Bibliographic Details
Main Authors: Pereira, Jose H., McAndrew, Ryan P., Ralston, Corie Y., King, Jonathan A., Adams, Paul D., Sergeeva, Oksana Andrei
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Nature Publishing Group 2018
Online Access:http://hdl.handle.net/1721.1/113627

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