Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice
Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). Although human B cell reconstitution is robust and T cell reconstitution is reasonable in the reci...
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National Academy of Sciences