Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). Although human B cell reconstitution is robust and T cell reconstitution is reasonable in the reci...

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Bibliographic Details
Main Authors: Chen, Qingfeng, Khoury, Maroun, Chen, Jianzhu
Other Authors: David H. Koch Institute for Integrative Cancer Research at MIT
Format: Article
Published: National Academy of Sciences 2011
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