Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselect...

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Bibliographic Details
Main Authors: Shen, Xiaoqiang, Buchwald, Stephen Leffler
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Published: Wiley Blackwell 2013
Online Access:http://hdl.handle.net/1721.1/81938

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