A unifying model for mTORC1-mediated regulation of mRNA translation

he mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin, a drug with many clinical uses. mTORC1 regulates messenger RNA translation, but the overall translational program is poorly defined and no unifying model exists to explai...

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Bibliographic Details
Main Authors: Thoreen, Carson C., Chantranupong, Lynne, Wang, Tim, Gray, Nathanael S., Sabatini, David M., Keys, Heather Rochelle
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/85632

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