mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry
Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an onc...
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Cold Spring Harbor Laboratory Press