mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated in susceptibility to type 2 diabetes. We describe the ability of mammalian target of rapamycin (mTOR) to regulate the cap-independent translation of IGF2 mRNA through phosphorylation of IMP2, an onc...

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Bibliographic Details
Main Authors: Dai, Ning, Rapley, Joseph, Angel, Matthew, Yanik, Mehmet Fatih, Blower, Michael D., Avruch, Joseph
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2014
Online Access:http://hdl.handle.net/1721.1/88501

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