Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions

DNA is susceptible to alkylation damage by a number of environmental agents that modify the Watson-Crick edge of the bases. Such lesions, if not repaired, may be bypassed by Y-family DNA polymerases. The bypass polymerase Dpo4 is strongly inhibited by 1-methylguanine (m1G) and 3-methylcytosine (m3C)...

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Bibliographic Details
Main Authors: Rechkoblit, Olga, Delaney, James C., Essigmann, John M., Patel, Dinshaw J.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier 2014
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