A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils

The tetrameric protein transthyretin is a transporter of retinol and thyroxine in blood, cerebrospinal fluid, and the eye, and is secreted by the liver, choroid plexus, and retinal epithelium, respectively. Systemic amyloid deposition of aggregated transthyretin causes hereditary and sporadic amyloi...

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Main Authors: Saelices, Lorena, Nguyen, Binh A., Chung, Kevin, Wang, Yifei, Ortega, Alfredo, Lee, Ji H., Coelho, Teresa, Bijzet, Johan, Benson, Merrill D., Eisenberg, David S.
Format: Online
Language:en_US
Published: American Society for Biochemistry and Molecular Biology 2020
Online Access:Saelices, L., Nguyen, B. A., Chung, K., Wang, Y., Ortega, A., Lee, J. H., Coelho, T., Bijzet, J., Benson, M. D., & Eisenberg, D. S. (2019). A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils. The Journal of biological chemistry, 294(15), 6130–6141. https://doi.org/10.1074/jbc.RA118.005257
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