A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH
Transthyretin (TTR) is a major amyloidogenic protein associated with hereditary (ATTRm) and nonhereditary (ATTRwt) intractable systemic transthyretin amyloidosis. The pathological mechanisms of ATTR-associated amyloid fibril formation are incompletely understood, and there is a need for identifying...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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Format: | Online |
Language: | English |
Published: |
Elsevier
2021
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Online Access: | Ueda, M., Okada, M., Mizuguchi, M., Kluve-Beckerman, B., Kanenawa, K., Isoguchi, A., Misumi, Y., Tasaki, M., Ueda, A., Kanai, A., Sasaki, R., Masuda, T., Inoue, Y., Nomura, T., Shinriki, S., Shuto, T., Kai, H., Yamashita, T., Matsui, H., … Ando, Y. (2019). A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH. Journal of Biological Chemistry, 294(29), 11259–11275. https://doi.org/10.1074/jbc.RA119.007851 |
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