Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity

AIMS: We have previously shown that the (±)-[(13) C]-pantoprazole breath test is a promising noninvasive probe of CYP2C19 activity. As part of that trial, plasma, breath test indices and CYP2C19 (*2, *3, and *17) genotype were collected. Here, we examined whether [(13) C]-pantoprazole exhibits en...

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Bibliographic Details
Main Authors: Thacker, David L., Modak, Anil, Nguyen, Phuong D., Flockhart, David A., Desta, Zeruesenay
Format: Online
Language:en_US
Published: Wiley 2015
Online Access:Thacker, D. L., Modak, A., Nguyen, P. D., Flockhart, D. A., & Desta, Z. (2011). Stereoselective Pharmacokinetics of Stable Isotope (+/−)-[13C]-Pantoprazole: Implications for a Rapid Screening Phenotype Test of CYP2C19 Activity. Chirality, 23(10), 904–909. http://doi.org/10.1002/chir.21011
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