Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals and in 16,491 T2D cases and 81,877 controls. We identify a novel association o...

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Main Authors: Wessel, Jennifer, Chu, Audrey Y., Willems, Sara M., Wang, Shuai, Yaghootkar, Hanieh, Brody, Jennifer A., Dauriz, Marco, Hivert, Marie-France, Raghavan, Sridharan, Lipovich, Leonard, Hidalgo, Bertha, Fox, Keolu, Huffman, Jennifer E., An, Ping, Lu, Yingchang, Rasmussen-Torvik, Laura J., Grarup, Niels, Ehm, Margaret G., Li, Li, Baldridge, Abigail S., Stančáková, Alena, Abrol, Ravinder, Besse, Céline, Boland, Anne, Bork-Jensen, Jette, Fornage, Myriam, Freitag, Daniel F., Garcia, Melissa E., Guo, Xiuqing, Hara, Kazuo, Isaacs, Aaron, Jakobsdottir, Johanna, Lange, Leslie A., Layton, Jill C., Li, Man, Hua Zhao, Jing, Meidtner, Karina, Morrison, Alanna C., Nalls, Mike A., Peters, Marjolein J., Sabater-Lleal, Maria, Schurmann, Claudia, Silveira, Angela, Smith, Albert V., Southam, Lorraine, Stoiber, Marcus H., Strawbridge, Rona J., Taylor, Kent D., Varga, Tibor V., Allin, Kristine H., Amin, Najaf, Aponte, Jennifer L., Aung, Tin, Barbieri, Caterina, Bihlmeyer, Nathan A., Boehnke, Michael, Bombieri, Cristina, Bowden, Donald W., Burns, Sean M., Chen, Yuning, Chen, Yii-DerI, Cheng, Ching-Yu, Correa, Adolfo, Czajkowski, Jacek, Dehghan, Abbas, Ehret, Georg B., Eiriksdottir, Gudny, Escher, Stefan A., Farmaki, Aliki-Eleni, Frånberg, Mattias, Gambaro, Giovanni, Giulianini, Franco, Goddard, William A., Goel, Anuj, Gottesman, Omri, Grove, Megan L., Gustafsson, Stefan, Hai, Yang, Hallmans, Göran, Heo, Jiyoung, Hoffmann, Per, Ikram, Mohammad K., Jensen, Richard A., Jørgensen, Marit E., Jørgensen, Torben, Karaleftheri, Maria, Khor, Chiea C., Kirkpatrick, Andrea, Kraja, Aldi T., Kuusisto, Johanna, Lange, Ethan M., Lee, I. T., Lee, Wen-Jane, Leong, Aaron, Liao, Jiemin, Liu, Chunyu, Liu, Yongmei, Lindgren, Cecilia M., Linneberg, Allan, Malerba, Giovanni, Mamakou, Vasiliki, Marouli, Eirini, Maruthur, Nisa M., Matchan, Angela, McKean-Cowdin, Roberta, McLeod, Olga, Metcalf, Ginger A., Mohlke, Karen L., Muzny, Donna M., Ntalla, Ioanna, Palmer, Nicholette D., Pasko, Dorota, Peter, Andreas, Rayner, Nigel W., Renström, Frida, Rice, Ken, Sala, Cinzia F., Sennblad, Bengt, Serafetinidis, Ioannis, Smith, Jennifer A., Soranzo, Nicole, Speliotes, Elizabeth K., Stahl, Eli A., Stirrups, Kathleen, Tentolouris, Nikos, Thanopoulou, Anastasia, Torres, Mina, Traglia, Michela, Tsafantakis, Emmanouil, Javad, Sundas, Yanek, Lisa R., Zengini, Eleni, Becker, Diane M., Bis, Joshua C., Brown, James B., Adrienne Cupples, L., Hansen, Torben, Ingelsson, Erik, Karter, Andrew J., Lorenzo, Carlos, Mathias, Rasika A., Norris, Jill M., Peloso, Gina M., Sheu, Wayne H.-H., Toniolo, Daniela, Vaidya, Dhananjay, Varma, Rohit, Wagenknecht, Lynne E., Boeing, Heiner, Bottinger, Erwin P., Dedoussis, George, Deloukas, Panos, Ferrannini, Ele, Franco, Oscar H., Franks, Paul W., Gibbs, Richard A., Gudnason, Vilmundur, Hamsten, Anders, Harris, Tamara B., Hattersley, Andrew T., Hayward, Caroline, Hofman, Albert, Jansson, Jan-Håkan, Langenberg, Claudia, Launer, Lenore J., Levy, Daniel, Oostra, Ben A., O'Donnell, Christopher J., O'Rahilly, Stephen, Padmanabhan, Sandosh, Pankow, James S., Polasek, Ozren, Province, Michael A., Rich, Stephen S., Ridker, Paul M., Rudan, Igor, Schulze, Matthias B., Smith, Blair H., Uitterlinden, André G., Walker, Mark, Watkins, Hugh, Wong, Tien Y., Zeggini, Eleftheria, Laakso, Markku, Borecki, Ingrid B., Chasman, Daniel I., Pedersen, Oluf, Psaty, Bruce M., Shyong Tai, E., van Duijn, Cornelia M., Wareham, Nicholas J., Waterworth, Dawn M., Boerwinkle, Eric, Linda Kao, W. H., Florez, Jose C., Loos, Ruth J. F., Wilson, James G., Frayling, Timothy M., Siscovick, David S., Dupuis, Josée, Rotter, Jerome I., Meigs, James B., Scott, Robert A., Goodarzi, Mark O.
Format: Online
Language:en_US
Published: Nature Publishing Group 2016
Online Access:Wessel, J., Chu, A. Y., Willems, S. M., Wang, S., Yaghootkar, H., Brody, J. A., … Goodarzi, M. O. (2015). Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. Nature Communications, 6, 5897. http://doi.org/10.1038/ncomms6897
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