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1“...-specific anti-apoptotic protein Bcl-x[subscript L] to remove its interactions with many of its binding...”
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2by Ryan, Jeremy, Letai, Anthony, Dutta, Sanjib, Chen, T. Scott, Kougentakis, Christos, Keating, Amy E.“... this mechanism in response to diverse signals. The five pro-survival proteins Bcl-x[subscript L], Mcl-1, Bcl-2...”
Published 2017
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3by Dutta, Sanjib, Gulla, Stefano, Fire, Emiko, Keating, Amy E., Chen, T. Scott, Grant, Robert A“... and SPOT peptide array analysis—to elucidate specificity determinants for binding to Bcl-x[subscript L...”
Published 2012
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5“... an alpha-helical structure and bind to a groove on prosurvival partners Bcl-x[subscript L], Bcl-w, Bcl-2...”
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6“... models of the corresponding peptide–receptor complexes. For two prominent players, Bcl-xL and Mcl-1, we...”
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7by Jenson, Justin Michael, Xue, Vincent, Stretz, Lindsey, Mandal, Tirtha, Reich, Lothar, Keating, Amy E.“... landscape for three members of the Bcl-2 family of proteins: Bcl-xL, Mcl-1, and Bfl-1. We applied...”
Published 2022
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8by Ryan, Jeremy A., Letai, Anthony, Foight, Glenna W., Gulla, Stefano V., Keating, Amy E.“... that showed moderate specificity and affinity for binding to Mcl-1 over Bfl-1, Bcl-x[subscript L], Bcl-2...”
Published 2017
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9“... motifs in pro-apoptotic proteins. Mammalian pro-survival proteins Bcl-x[subscript L], Bcl-2, Bcl-w, Mcl-1...”
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11“... to their affinities for the anti-apoptotic protein Bcl-x[subscript L]. Our results are in striking agreement...”
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12by Hiraki, Masayuki, Maeda, Takahiro, Mehrotra, Neha, Jin, Caining, Alam, Maroof, Bouillez, Audrey, Hata, Tsuyoshi, Tagde, Ashujit, Keating, Amy E., Kharbanda, Surender, Singh, Harpal, Kufe, Donald“..., which inhibits BCL-2, BCL-xL and BCL-W but not MCL-1 or BCL2A1, is associated with the upregulation...”
Published 2020
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