Showing 1 - 20 results of 91 for search 'M.', query time: 0.12s Refine Results
  1. 1
    A unifying model for mTORC1-mediated regulation of mRNA translation
    “...he mTOR complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation...”
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  2. 2
    Rapamycin inhibits mTORC1, but not completely
    by Thoreen, Carson C, Sabatini, David
    Published 2012
    “...Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex...”
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  3. 3
    mTOR Signaling in Growth, Metabolism, and Disease
    “...© 2017 Elsevier Inc. The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth...”
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  4. 4
    Regulation of mTORC1 by amino acids
    by Bar-Peled, Liron, Sabatini, David
    Published 2017
    “...The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular...”
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  5. 5
    An emerging role of mTOR in lipid biosynthesis
    by Laplante, Mathieu, Sabatini, David
    Published 2012
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  6. 6
    mTOR Signaling in Growth Control and Disease
    “...The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety...”
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  7. 7
    A Central Role for mTOR in Lipid Homeostasis
    “...The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic...”
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  8. 8
    mTOR and cancer: many loops in one pathway
    by Efeyan, Alejo, Sabatini, David
    Published 2012
    “...The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division...”
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  9. 9
    The TSC-mTOR pathway regulates macrophage polarization
    “...Macrophages are able to polarize to proinflammatory M1 or alternative M2 states with distinct...”
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  10. 10
    SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
    “...mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental...”
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  11. 11
    Amino acids and mTORC1: from lysosomes to disease
    “...The mechanistic target of rapamycin (mTOR) kinase controls growth and metabolism, and its...”
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  12. 12
    Nutrients versus growth factors in mTORC1 activation
    “...Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin...”
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  13. 13
    Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
    “...Rapamycin, an inhibitor of mTOR complex 1 (mTORC1), improves insulin sensitivity in acute studies...”
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  14. 14
    mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
    “...The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein kinase promotes growth...”
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  15. 15
    Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
    “... to be necessary for amino acid−induced activation of mTORC1. The RagC variants increased raptor binding while...”
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  16. 16
    Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
    “...The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth...”
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  17. 17
    mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
    “...The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein kinase promotes growth...”
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  18. 18
    mTOR: from growth signal integration to cancer, diabetes and ageing
    “... (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K...”
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  19. 19
    Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
    “... target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance...”
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  20. 20
    Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
    “...mTOR is a highly conserved serine/threonine protein kinase that serves as a central regulator...”
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