Showing 1 - 20 results of 22 for search 'D.', query time: 0.16s Refine Results
  1. 1
    An endogenous dAMP ligand in
    “...) that maintains proper deoxynucleotide pool sizes and ratios in vivo. In class Ia RNRs, ATP (stimulatory) and d...”
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  2. 2
    Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer
    “... crystal structure of the human α subunit in the presence of inhibiting levels of dATP, depicting a ring...”
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  3. 3
    Incorporation of Fluorotyrosines into Ribonucleotide Reductase Using an Evolved, Polyspecific Aminoacyl-tRNA Synthetase
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  4. 4
    Clofarabine 5′-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit
    by Aye, Yimon, Stubbe, JoAnne
    Published 2011
    “... NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs (dATP, dGTP, TTP) allosteric...”
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  5. 5
    Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase
    “..., U, G, or A) to 2′-deoxynucleotides (dNDPs or dNTPs)[superscript 1] and are responsible...”
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  6. 6
    3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound
    “... resolution structure by cryo-electron microscopy (EM) of a dATP-inhibited state of human RNR. This structure...”
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  7. 7
    Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase
    “... (dNDPs). β2 contains the essential tyrosyl radical (Y[subscript 122][superscript •]) that generates a...”
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  8. 8
    Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase
    “... to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation...”
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  9. 9
    Redox-Linked Changes to the Hydrogen-Bonding Network of Ribonucleotide Reductase β2
    “... of D84, a unidentate ligand to the diferric cluster. The results are consistent with a redox-induced...”
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  10. 10
    DNA oligonucleotides with A, T, G or C opposite an abasic site: structure and dynamics
    “...) and characterized by 2D NMR spectroscopy. Studies on a duplex DNA with an A opposite the abasic site in the same...”
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  11. 11
    Use of 2,3,5-F[subscript 3]Y-beta 2 and 3-NH[subscript 2]Y-alpha 2 To Study Proton-Coupled Electron Transfer in Escherichia coli Ribonucleotide Reductase
    “... of nucleoside 5′-diphosphates (NDPs) to deoxynucleotides (dNDPs). The active site for NDP reduction resides in α...”
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  12. 12
    Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases
    “... of nucleoside 5′-diphosphates (NDPs) to 2′-deoxynucleotides (dNDPs). The reaction is initiated by the transient...”
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  13. 13
    Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase
    “... in the presence of the negative activity effector dATP and provide structural support for an active α2β2...”
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  14. 14
    Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo
    by Cotruvo, Joseph A., Stubbe, JoAnne
    Published 2012
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  15. 15
    Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers
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  16. 16
    Mechanistic Insight with HBCH[subscript 2]CoA as a Probe to Polyhydroxybutyrate (PHB) Synthases
    “...-([[superscript 3]H]-sD-CO[subscript 2]H), and trimer-acid ([[superscript 3]H]-sT-CO[subscript 2]H), distinct from...”
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  17. 17
    A hot oxidant, 3-NO[subscript 2]Y[subscript 122] radical, unmasks conformational gating in reductase
    “... with biphasic kinetics (283 and 67 s[superscript −1]), that dCDP is produced at 107 s[superscript −1...”
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  18. 18
    ENDOR Spectroscopy and DFT Calculations: Evidence for the Hydrogen-Bond Network Within α2 in the PCET of E. coli Ribonucleotide Reductase
    “..., cytidine 5′-diphosphate, and adenosine 5′-triphosphate to generate a NH2Y730• in D2O. [[superscript 2]H...”
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  19. 19
    Re(bpy)(CO)[subscript 3]CN as a Probe of Conformational Flexibility in a Photochemical Ribonucleotide Reductase
    “... of Y356. The diffusion coefficient of [Re]-Y-βC19 has been measured (k[subscript d1] = 6.1 × 10...”
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  20. 20
    Bacillus subtilis Class Ib Ribonucleotide Reductase Is a Dimanganese(III)-Tyrosyl Radical Enzyme
    by Zhang, Yan, Stubbe, JoAnne
    Published 2012
    “...[superscript•] and Fe(III)[subscript 2-]Y[superscript•] rNrdF generate dCDP at rates of 132 and 10 nmol min...”
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