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61by Frederick, Kendra K., Linse, Sara, Silvers, Robert Paul Georg, Colvin, Michael Thomas, Jacavone, Angela, Lindquist, Susan, Griffin, Robert Guy“... compared aggregation kinetics with AβM01–42 containing the additional methionine residue. The data revealed...”
Published 2018
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62by Gangaramani, Paritosh, Thompson, Mary Katherine, Gilbert, Wendy, Rojas Duran, Maria Fernanda“.... Here we show that eukaryote-specific Asc1/RACK1 is required for efficient translation of m...”
Published 2016
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64“...Alternative splicing and mRNA editing are known to contribute to transcriptome diversity. Although...”
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65by Yoshii, Akira, Murata, Yasunobu, Kim, Jihye, Shokat, Kevan M., Constantine-Paton, Martha, Zhang, Chao, Ph. D. Massachusetts Institute of Technology“... M ζ (PKMζ). We find that PKMζ selectively regulates phosphorylation of the palmitoylation enzyme...”
Published 2012
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66“...Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus...”
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67by Chung, J., Bauer, D. E., Ghamari, A., Nizzi, C. P., Deck, K. M., Kingsley, P. D., Yien, Y. Y., Huston, N. C., Chen, C., Schultz, I. J., Dalton, A. J., Wittig, J. G., Palis, J., Orkin, S. H., Eisenstein, R. S., Cantor, A. B., Paw, B. H., Lodish, Harvey F“... the mTORC1 (mammalian target of rapamycin complex 1)/4E-BP (eukaryotic translation initiation factor 4E...”
Published 2017
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68by Katajisto, Pekka, Lamming, Dudley W., Gultekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zuckerberg, Lawrence, Bahn, Atul K., Deshpande, Vikram, Yilmaz, Omer, Sabatini, David“... by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC...”
Published 2012
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69“...Most eukaryotic mRNAs are recruited to the ribosome by recognition of a 5ʹ m7GpppN cap. 30 years...”
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70by Wagle, N., Grabiner, Brian C., Van Allen, E. M., Hodis, Eran, Jacobus, S., Supko, J. G., Stewart, M., Choueiri, T. K., Gandhi, L., Cleary, J. M., Elfiky, A. A., Taplin, M. E., Stack, E. C., Signoretti, S., Loda, Massimo, Shapiro, G. I., Gabriel, Stacey B., Kantoff, Philip W., Garraway, Levi A., Rosenberg, J. E., Sabatini, David, Lander, Eric Steven“... complete response on this trial revealed two concurrent mutations in mTOR, the target of everolimus...”
Published 2015
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71by Lander, Eric Steven“... (PI3K/mTOR) pathway as a central vulnerability for therapeutic exploitation in osteosarcoma...”
Published 2015
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72“...UPF1 is a DNA/RNA helicase with essential roles in nonsense-mediated mRNA decay (NMD) and embryonic...”
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73“...mTOR complex I (mTORC1) is a central growth regulator that senses amino acids through a pathway...”
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74“...The oocyte-to-embryo transition involves extensive changes in mRNA translation, regulated...”
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75by Sancak, Yasemin, Bar-Peled, Liron, Zoncu, Roberto, Markhard, Andrew L., Nada, Shigeyuki, Sabatini, David“...The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids...”
Published 2012
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76by Schwartz, Schraga, Mumbach, Maxwell R., Jovanovic, Marko, Mertins, Philipp, Shishkin, Alexander, Tabach, Yuval, Mikkelsen, Tarjei S., Satija, Rahul, Ruvkun, Gary, Carr, Steven A., Regev, Aviv, Agarwala, Sudeep, Lander, Eric Steven, Fink, Gerald R.“...N[superscript 6]-methyladenosine (m[superscript 6]A) is the most ubiquitous mRNA base modification...”
Published 2017
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77by Regev, Aviv“...Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily...”
Published 2020
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78by Chan, Sze Ham, Freinkman, Elizaveta, Abu-Remaileh, Monther, Wyant, Gregory Andrew, Kim, Choah, Laqtom, Nouf N, Abbasi, Maria, Sabatini, David“..., an effect we traced to regulation of the mechanistic target of rapamycin (mTOR) pathway. Inhibition of m...”
Published 2019
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79by Plovanich, M. E., Straub, C., Sabatini, B. L., Tsun, Zhi-Yang, Wang, Shuyu, Wolfson, Rachel Laura, Shen, Kuang, Wyant, Gregory Andrew, Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William C., Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Kim, Choah, Park, Jiwon, Sabatini, David“...The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator...”
Published 2015
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